Regenerative biology and medicine

Elsevier

2012

474 p.

9780123848604

Contents: Part I Regenerative Biology; 1. An Overview of Regenerative Biology; I. Introduction; II. A Brief History of Regenerative Biology; III. Regeneration Occurs at All Levels of Biological Organization; IV. Mechanisms of Vertebrate Regeneration; V. The Niche Concept in Tissue Repair; VI. Approaches to the Study of Regeneration; Summary; References; 2. Repair of Skin by Fibrosis; I. Introduction; II. Structure of Adult Mammalian Skin; III. Phases of Repair By Fibrosis; IV. Tattoos and Fetal Skin Have a Minimal Immune Response to Wounding; V. Comparative Molecular Analysis of Wound Repair; Summary; References; 3. Regeneration of Epidermal Structures; I. Introduction; II. Maintenance Regeneration of Interfollicular Epidermis and Hair; III. Regeneration of Nails; IV. Regeneration of Cornea; V. Regeneration of the Lens; VI. Regeneration of Avian and Mammalian Auditory Sensory Cells; Summary; References; 4. Regeneration of Neural Tissues; I. Introduction; II. Structure of the Nervous System; III. Regeneration of Axons; IV. Neurogenesis in the Adult CNS; Summary; References; 5. Regeneration of Digestive, Respiratory and Urinary Tissues; I. Introduction; II. Regeneration of the Intestinal Epithelium; III. Regeneration of the Liver; IV. Regeneration of the Pancreas; V. Regeneration of Respiratory Epithelium; VI. Regeneration of Kidney Tubule Epithelium; Summary; References; 6. Regeneration of Musculoskeletal Tissues; I. Introduction; II. Regeneration of Skeletal Muscle; III. Regeneration of Bone; IV. Regeneration of Articular Cartilage, Meniscus, Tendon and Ligament; V. Regeneration of Dental Tissues; Summary; References; 7. Regeneration of Cardiac Muscle and Hematopoietic Tissues; I. Introduction; II. Regeneration of Cardiac Muscle; III. Regeneration of Hematopoietic Cells; Summary; References; 8. Regeneration of Appendages; I. Introduction; II. Urodele Limb Regeneration; III. What Inhibits Limb Regeneration in Adult Frogs, Birds and Mammals?; IV. Regeneration of Mammalian Appendages; V. Stimulation of Regeneration in Anuran and Mammalian Appendages; VI. Comparative Analysis as a Tool to Understand Limb Regeneration; Summary; References; Part II Regenerative Medicine; 9. Strategies of Regenerative Medicine; I. Introduction; II. Biomimetic Devices and Organ Transplant; III. Cell Transplants; IV. Bioartificial Tissue Construction; V. Chemical Induction of Regeneration in situ; Summary; References; 10. Regenerative Medicine of Epidermal Structures; I. Introduction; II. Repair of Skin Wounds and Burns; III. Stimulation of Hair Regeneration; IV. Limbal Cell Transplants to Regenerate the Cornea; Summary; References; 11. Regenerative Medicine of Neural Tissues; I. Introduction; II. Therapies for Regeneration of Peripheral Nerves; III. Therapies for Trauma to the Mammalian Central Nervous System; IV. Therapies for Neurodegenerative Diseases; Summary; References; 12. Regenerative Therapies for Digestive, Respiratory and Urinary Tissues; I. Introduction; II. Regenerative Therapies for the Liver; III. Regenerative Therapies for the Pancreas; IV. Regenerative Therapies for the Esophagus and Intestine; V. Regenerative Therapies for the Respiratory System; VI. Regenerative Therapies for the Urinary System; Summary; References; 13. Regenerative Therapies for Musculoskeletal Tissues; I. Introduction; II. Therapies for Skeletal Muscle; III. Regenerative Therapies for Articular Cartilage; IV. Regenerative Therapies for Meniscus; V. Regenerative Therapies for Non-Union Fractures and Critical Size Gaps in Bone; VI. Regenerative Therapies for Teeth and Periodontium; VII. Regenerative Therapies for Tendon and Ligament; Summary; References; 14. Regenerative Therapies for Hematopoietic and Cardiovascular Tissues; I. Introduction; II. Therapies for Hematopoietic Disorders; III. Therapies for Damaged Blood Vessels; IV. Therapies for Infarcted Myocardium; Summary; References; Part III Perspective; 15. Retrospect and Prospect; I. Introduction; II. Achievements and Challenges; III. Bioethics in Regenerative Medicine; IV. Exciting Future Prospects for Regenerative Biology and Medicine; V. Concluding Remarks; References; Index.

Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering.

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