Randomized Comparative Trial with Ampicillin/Sulbactam versus Cefamandole in the Therapy...

In a randomized prospective study ampicillin/sulbactam and cefamandole were compared in the therapy of patients hospitalized with community acquired pneumonia. Patients receiving ampicillin/sulbactam (n=37) and cefamandole (n=38) were similar with respect to age (mean age 70 vs. 76 years respectively), clinical characteristics, severity of illness and underlying disease. Pathogens isolated from patients in the cefamandole and ampicillin/sulbactam group, respectively, were Streptococcus pneumoniae (7 vs. 7 patients), Haemophilus parainfluenzae (7 vs. 6 patients),Haemophilus influenzae (5 vs. 5 patients),Staphylococcus aureus (5 vs. 4 patients),Escherichia coli (4 vs. 4 patients),Klebsiella pneumoniae (3 vs. 3 patients),Enterobacter spp. (2 vs. 3 patients),Moraxella catarrhalis (1 vs. 2 patients), and organisms of the oral flora (4 vs. 3 patients). The rate of resistance to penicillin was 80 %, to clindamycin 76 %, to erythromycin 45 %, to ampicillin 43 %, and to cefazolin 18 %. Overall successful treatment rates of 81 % for cefamandole and 97 % for ampicillin/sulbactam (p=0.05) were observed. Both cefamandole and ampicillin/sulbactam were shown to be effective agents for therapy of community acquired pneumonia; however ampicillin/sulbactam demonstrated superior overall clinical efficacy.

Английский

European Journal of Clinical Microbiology and Infectious Diseases. – 1994. – Vol. 13, № 4. – P. 293–298.