Infections causing human cancer

Wiley-VCH

2006

xiv, 517 p.

9783527310562

Contents: Historical review -- The Quest for causality -- Tumors linked to infections: some general aspects -- Herpesviruses and oncogenesis -- Papillomavirus infections: a major cause of human cancers -- Hepadnaviruses -- Flaviviruses -- Retrovirus family -- Other virus infections possibly involved in human cancers -- Helicobacter, chronic inflammation, and cancer -- Parasites and human cancers -- Cancers with a possible infectious etiology.

Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in the development of novel therapeutic and preventive strategies. In this book, Professor zur Hausen (Nobel Prize in Physiology/Medicine 2008) provides a thorough and comprehensive overview on carcinogenic infective agents -- viruses, bacteria, parasites and protozoons -- as well as their corresponding transforming capacities and mechanisms. The result is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer. The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early as 1976, published the hypothesis that wart viruses play a role in the development of this type of cancer.

Английский