Genomic and precision medicine

Elsevier Science

2016

xvi, 381 p.

9780128006566

1. Application of Human Genome Information to Clinical Practice; 1a. Genome sequencing: new technologies, approaches, applications; 1b. Clinical applications of whole-genome chromosomal microarray analysis; 1c. Transcriptomics in the age of ultra high-throughput sequencing; 1d. Quantitative Proteomics in Genomic Medicine; 2. Translating genome information into clinical practice and human health; 3. Big Data and Translational Bioinformatics Genomic and Personalized Medicine; 3a. Biospecimen Banking linked to phenotype data; 3b. Electronic Health Records; 3c. Data Sharing and Privacy; 4. Designing Genome-Based Clinical Studies; 5. Developing the Evidence to Support Clinical Use Genomic Biomarkers as Diagnostics; 5a. Strategies in the Adoption of Genome-Based Diagnostics; 5b. Companion Diagnostics; 6. Health Risk Assessment and Family History; 7. Clinical Decision Support; 8. Implementation Science and Integration into Healthcare Systems; 9. Pharmacogenetics and Pharmacogenomics; 10. Drug Repurposing and Repositioning; 11. Point of Care Devices; 12. Overview of Policy, Ethical and Social Considerations; 13. Educational Issues and Strategies for Genomic Medicine; 13a. For Professionals; 13b. For The Public; 14. Regulation of Genomic Technologies; 15. Economic Value of Genomic Medicine; 16. Reimbursement; 17. Impact of Patents on Genomic Medicine.

Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care. * Provides a comprehensive volume on the translation and implementation of biology into health care provision * Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation * Includes an up-to-date overview on major 'translational events' in genomic and personalized medicine, along with lessons learned

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