Etude comparative de deux modes d'antibioprophylaxie en chirurgie prostatique endoscopique

This study compares a short antibioprophylaxis of 24 hours to a single injection treatment by cefamandole in endoscopic resection of the prostate. 122 patients were separated in two groups by randomisation. 61 patients received 1.5 g of cefamandole at induction of anaesthesia and 750 mg every six hours during 24 hours after surgery. The other 61 patients received a single injection of 1.5 g of cefamandole at the induction of anaesthesia. Both series were comparable in age, prostatic pathology, time of resection, weight to the resected prostate, the day of removal of the urinary catheter, the day of departure. In the first group, we found eight obvious infections and 10 occult infections with positive urinary microscopic examination; and in the second group, we found 11 obvious ans 4 occult infections with positive urinary microscopic examination. In both infected groups, we found mainly Pseudomonas aeruginosa. Both treatments were equally well accepted. The authors prefer the single injection treatment because of the low cost and absence of statistically significant differences between the two treatments.

Французский

Pathologie-Biologie (Paris). – 1989. – Vol. 37, № 5, pt. 2. – P. 677–680.